Compound Zinc Iron Calcium Oral Solution Instructions
Please read the instructions carefully and use them under the guidance of a physician.

[Name of Drug]]English name: CompoundZincGluconate,Ferrous Gluconate and Calcium Gluconate Oral Solution. Chinese Pinyin: FufangXintiegaiKoufurongye

[ingredients]]
This product is a compound preparation, its components are ferrous gluconate 100 mg (equivalent to 12 mg of iron), zinc gluconate 30 mg (equivalent to 4.3 mg of zinc), calcium gluconate 400 mg (equivalent to 36 mg of calcium), vitamin Bz3 mg.

character]
This product is yellow to brownish red liquid, long-standing trace precipitation; sweet and sour taste.

indications]
For zinc, iron, calcium deficiency caused by related diseases.
[specification]]
Each 10m1 contains 100 mg of ferrous gluconate (equivalent to 12 mg of iron), 30 mg of zinc gluconate (equivalent to 4.3 mg of zinc), 400 mg of calcium gluconate (equivalent to 36 mg of calcium) and 23 mg of vitamin B23.
Usage and dosage]

Oral. Adults: 3 times a day, 1 once; 1-10 years old: 2 times a day, 1 once; 6-12 months: 1 once a day; Half a day under 6 months.

adverse reaction]

1, iron after oral administration are astringent, often mild nausea, stomach or abdominal pain, mostly dose-related, mild diarrhea or constipation is also very common. 2, zinc has gastrointestinal irritation, oral can have mild nausea, vomiting and constipation. 3, calcium according to the recommend dose, few adverse reactions, may have belching, constipation, abdominal discomfort. 4. Rare adverse reactions are hypercalcemia and kidney stones, which are easy to occur when long-term or large-scale use or suffer from renal damage, such as anorexia, nausea, vomiting, constipation, abdominal pain, muscle weakness, arrhythmia, confusion, hypertension and bone lime deposition.
taboo]

1. Hemosiderosis and other anemia patients without iron deficiency are disabled. 2, blood color disease patients disabled. 3, liver and kidney function seriously damaged disabled. 4, iron allergy disabled. 5, or active peptic ulcer patients disabled. 6, hypercalcemia, hypercalciuria patients disabled. 7. Patients with calcium-containing kidney stones or a history of kidney stones are disabled. 8, sarcoid disease (can aggravate hypercalcemia) patients disabled. 9. Those who are allergic to any ingredient of this product are prohibited.

[Note]]

1, should be taken according to the recommend dose, not overdose. 2. Iron should be used with caution in the following situations:(1) alcoholism;(2) hepatitis;(3) acute infection;(4) intestinal inflammation such as enteritis, colitis, resting room inflammation and ulcerative colitis;(5) Pancreatitis;(6) Peptic ulcer. 3. During the use of iron, the following examinations should be done regularly to observe the therapeutic response:(1) hemoglobin determination;(2) reticulocyte count;(3) serum iron egg self and serum iron determination. Should be taken when diagnosed with zinc deficiency, such as long-term use, must be used under the guidance of a physician. 4, the diagnosis of interference: taking iron can make the serum binding to transferrin or iron egg self-increased, stool occult blood test positive; the former easily lead to missed diagnosis, the latter is confused with upper gastrointestinal bleeding. Long-term or large doses of calcium can cause serum phosphorus concentration decreased, 5, this product should be taken immediately after meals, can reduce the local intestinal irritation, should not be taken at the same time with milk. Should not be served with strong tea. 6, oral iron should not be used at the same time with the iron injection. To avoid toxic reactions. 7, chronic diarrhea or gastrointestinal absorption dysfunction with caution (poor absorption of calcium, and intestinal excretion of calcium increased, at this time the need for calcium increased). 8, chronic renal insufficiency with caution (kidney to reduce calcium excretion, pay attention to hypercalcemia). 9, ventricular fibrillation with caution. 10, a large number of long-term medication should be regularly measured serum calcium concentration, urinary calcium excretion; serum potassium, magnesium, phosphorus concentration; blood pressure and electrocardiogram. 11. Use with caution during taking digitalis drugs. Keep this medicine out of the reach of children. 12. Children must be used under adult supervision. 13. When the character of this product is changed, it is forbidden when the flounder is afraid of the ladle, the storage painting, the г, the corpse, and the leech store.

Medication for pregnant and lactating women]
Pregnant women and lactating women generally need to supplement iron and zinc and other elements, but the dosage should be prescribed. Iron supplementation during pregnancy should be most appropriate in the middle and late stages of pregnancy, when iron intake decreases and demand increases. Adverse effects of therapeutic doses of iron on the fetus and lactation have not been reported.
Pregnant women and lactating women generally need to supplement calcium, but the dosage should be prescribed. At present, there is no animal and human experiment on the effect of calcium on the fetus. Some calcium can be secreted by milk, but its concentration is not enough to cause adverse reactions of calcium in newborns and infants.
children medication]
6-12 months: 1 per day; Half a day for less than 6 months.
[elderly medication] elderly patients with iron supplement, used to treat iron deficiency anemia, if necessary, can be appropriate to increase the dose, because of reduced gastric secretion, gastric acid deficiency, iron absorption from intestinal mucosa reduced. The elderly may be due to the active vitamin D, vitamin D, secretion, intestinal absorption of calcium is reduced, so the oral dose should be increased accordingly.

drug interaction]
1, iron and acid drugs such as sodium bicarbonate, phosphate and tannic acid containing drugs or drinks with, easy to produce precipitation and affect the absorption of this product.
2, iron and vitamin C with service, can increase the absorption of iron, but also easily lead to gastrointestinal reactions.
3, cimetidine, desferrioxamine, two mercaptopropanol, pancreatin, pancreatic lipase can affect the absorption of iron.
4, iron can affect the absorption of tetracyclines, fluoroquinolones, penicillamine and zinc preparations.
5, zinc and aluminum, calcium, strontium salt, borax, carbonate and hydroxide (alkali), protein silver and tannic acid are incompatible.
6. The combination of zinc and penicillamine can reduce the effect of the latter.
7, a large number of alcoholic and caffeinated beverages and a large number of smoking, will inhibit the absorption of oral calcium.
8. Eating a lot of food containing cellulose can inhibit the absorption of calcium, because calcium and cellulose are combined into compounds that are not easy to absorb.

9. This product is used with phenytoin or fluoride, and the absorption of both is reduced. This product can reduce the absorption of levodopa, carbidopa, methyldopa
10, vitamin D, oral contraceptives, estrogen can increase the absorption of calcium in this product.
11. When the antacid containing aluminum is taken with this product, the absorption of aluminum increases.
12. This product is prone to hypercalcemia when combined with thiazide diuretics.
13. When this product is combined with digitalis or potassium-containing drugs, attention should be paid to the occurrence of arrhythmia and must be very cautious.
14, and calcium channel blockers (such as nifedipine) with, blood calcium can be significantly increased to above normal, but the effect of verapamil hydrochloride is reduced.
15, with other calcium or magnesium containing drugs, prone to hypercalcemia or hypermagnesemia, especially when renal insufficiency.
[drug overdose] excessive amount of iron can lead to necrotizing gastritis and enteritis. Patients may have severe vomiting, diarrhea and abdominal pain, resulting in decreased blood pressure, metabolic acidosis and even coma and other acute poisoning symptoms. After 24-48 hours, severe poisoning can further develop to shock and hypovolemia, liver damage and cardiovascular failure, and patients can have systemic convulsions. Poisoning later symptoms of skin damp, cyanosis, lethargy, extreme fatigue and weakness, tachycardia. Acute signs of poisoning should be treated immediately with sodium calcium pentate or deferoxamine. After the poisoning is rescued, it is possible to have pylorus or stenosis, liver damage or
Central nervous system lesions should be properly handled as soon as possible. Acute poisoning caused by iron overdose is more common in children, and only 130mg of iron can cause death in children. Overdose of zinc leads to poisoning, which can be manifested as acute gastroenteritis, nausea, vomiting, abdominal pain, and diarrhea; the symptoms can disappear quickly after diarrhea, and gastrointestinal bleeding is occasionally seen in severe cases. It is caused by corrosive zinc chloride generated by hydrochloric acid and zinc in gastric juice, and there have been reports of intestinal perforation. Large doses or long-term use of calcium daily more than 2000~2500mg or the existence of renal damage, prone to overdose. Early manifestations of hypercalcemia include severe constipation, progressive dry mouth, persistent headache, loss of appetite, irritability, depression, metallic taste in the mouth, and muscle weakness. Later manifestations include drowsiness, confusion, hypertension, increased sensitivity of eyes and skin to light, arrhythmia, nausea, vomiting, increased urine volume and increased urination frequency. In severe hypercalcemia, the ECG 0-T interval may be short.
Exceeding treatment: mild hypercalcemia only needs to stop calcium and other calcium-containing drugs and reduce the calcium content in the diet. when the blood calcium concentration exceeds 2.9mmol(120mg/), the following measures should be taken immediately: ① infusion of sodium chloride injection and application of high-efficiency diuretics such as furosemide and bumetazanide to rapidly increase urinary calcium excretion; ② determination of serum potassium and magnesium concentrations, if decreased, should be corrected; ③ Monitor ECG and apply B receptor blocker to prevent severe arrhythmia; ④ Hemodialysis, calcitonin and adrenal cortical hormone therapy if necessary; ⑤ Follow up blood calcium concentration closely. pharmacology and toxicology]
Iron is a constituent element of hemoglobin in red blood cells. Iron deficiency, red blood cells to reduce the amount of synthetic hemoglobin, resulting in smaller red blood cell volume, oxygen carrying capacity decreased, the formation of iron deficiency anemia. Oral ferrous gluconate can supplement iron and correct iron deficiency anemia; zinc is an important component of many enzymes in the body, which can promote growth and development, improve taste and so on. When lacking, growth stagnation, reproductive incompetence, wound healing is not easy, the body is weak, conjunctivitis, stomatitis, glossitis, lack of appetite, chronic diarrhea, loss of taste, neurological symptoms and so on. Oral zinc gluconate can be corrected; calcium can be involved in bone formation and bone tissue reconstruction after fracture, as well as muscle contraction, neurotransmission, coagulation mechanisms and reduce capillary permeability. Oral calcium gluconate can supplement calcium deficiency; vitamin B is an important part of coenzyme, which participates in the metabolism of sugar, egg and fat, maintains normal visual function and promotes growth.
[Pharmacokinetics] Iron is mainly absorbed in duodenum and proximal jejunum in the form of ferrous ion (Fe "). For those who are not deficient in iron, 5% ~ 10% of oral intake of iron can be absorbed from intestinal mucosa. If the iron storage in the body is deficient, the absorption of iron can be increased proportionally, and generally 20% ~ 30% of intake of iron can be absorbed. When iron is taken with food, its absorption is reduced by 1/3~1/2 compared with that on an empty stomach. After iron absorption, it enters the blood circulation after being combined with the transferrin egg for erythropoiesis, and can also accumulate in the liver, spleen, bone marrow and other reticuloendothelial tissues in the form of ferritin or hemosiderin. The protein binding rate of iron is high in hemoglobin, and low in myoglobin, enzymes, and iron-transporting proteins. Ferritin or hemosiderin was also low. The total daily excretion of iron is 0.5~1.0mg, and the average daily excretion of women is about 1.5~2mg due to menstruation, pregnancy, lactation and other reasons. Metabolized iron is mainly excreted through the kidneys, unabsorbed iron is excreted from the feces, and a small amount of iron is excreted from bile, urine, and sweat.
Zinc is absorbed in duodenum and small intestine and stored in red and autogenous cells, muscle, bone, skin and other tissues. After entering blood, 60% of zinc is combined with serum eggs, 90% of zinc is excreted by feces, and trace amounts are excreted through urine.
Sweat, skin desquamation, hair shedding discharge. Normally, 1/5~1/3 of oral calcium is absorbed by the small intestine, vitamin D and alkaline environment promote the absorption of calcium, while cellulose and vegetable acid in food reduce the absorption of calcium. The absorption of calcium increases when there is a calcium deficiency in the body or when the calcium content in the diet is low. The plasma protein binding rate of calcium is about 45%. 80% of oral femoral calcium is excreted from feces, mainly unabsorbed calcium and 20% from kidney. Its excretion is related to renal function and bone calcium content.

storage]Closed and stored in a dry place.
[packaging]]Plastic bottle packaging, each box of 15
[validity period]]24 months
executive standard]State Drug Administration National Drug Standard WS:-XG-005-2022 [Approval Number] National Drug Standard H20090076
listing permit holder]Yueyang Xinhuada Pharmaceutical Co., Ltd
[address]]Wujiang Bridge, Yueyang Economic and Technological Development Zone
production enterprise]
Company: Yueyang Xinhuada Pharmaceutical Co., Ltd.
Production Address: Wujiang Bridge, Yueyang Economic and Technological Development Zone Postal Code: 414000
Telephone number: 0730-8258800
Fax number: 0730-8257700
Website: www.yyxhd.com
If you have any questions, please contact the production enterprise.